Publicaties van LCO
Het LUMC Centrum voor Ouderengeneeskunde (LCO) publiceert regelmatig (wetenschappelijke) artikelen over het werkgebied van het Centrum. Hieronder volgt het overzicht.
| Titel | Auteurs | Datum | Trefwoorden | Tijdschrift naam |
|---|---|---|---|---|
| Deprescribing antihypertensive medications in older people: a systematic review and a meta-analysis. | Floriani C et al. | 2026 | Antihypertensive treatment, Deprescribing, Older adults | BMC geriatrics |
| Considerations with respect to elective Abdominal Aortic Aneurysm repair in older people. | Biemond MJ et al. | 2025 | abdominal aortic aneurysm, age, elective repair, older people, rupture risk, sex | Annals of vascular surgery |
| Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts. | Hysaj O et al. | 2025 | Cardiovascular disease, Individual participant data analysis, Subclinical hypothyroidism, Thyroid peroxidase antibodies | European journal of endocrinology |
| Association between older adults’ socioeconomic status and their healthcare experiences, preferences, and attitudes towards deprescribing: a cross-sectional study in 14 countries. | Lüthold RV et al. | 2025 | Deprescribing, Older adults, Patient care, Polypharmacy, Socioeconomic status | Archives of public health = Archives belges de sante publique |
| Impact of geriatric impairments on outcomes of single-agent immunotherapy in solid tumors. | Özkan A et al. | 2025 | frailty, geriatric assessment, geriatric screening, immune checkpoint inhibitors, immune‐related adverse events | International journal of cancer |
| Response to letter Re: Impact of immune-related adverse events on quality of life and physical functioning in older patients with solid tumors treated with immune checkpoint inhibitors. | Özkan A et al. | 2025 | European journal of cancer (Oxford, England : 1990) | |
| Prescriptions of Essentially Placebo Treatments Among General Practitioners in 21 Countries. | Wolters F et al. | 2025 | JAMA network open | |
| Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis. | Jagosh J et al. | 2025 | PLoS medicine | |
| Clinical Frailty Scale, Surprise Question and One-year Mortality in Older Patients With Advanced CKD. | Demirhan I et al. | 2025 | Kidney360 | |
| Initiation of anti-osteoporosis medication following hip fracture in older adults: a systematic review and thematic synthesis of qualitative studies from patient and healthcare professional perspectives. | de Jong-Holthuijsen S et al. | 2025 | anti-osteoporosis medication, decision-making, hip fracture, older people, osteoporosis, qualitative, research | Age and ageing |
| “Who am I to say that I’m not going to take it”: patient perspectives on decisions about antithrombotic therapy in the context of advanced cancer. | Baddeley E et al. | 2025 | Antithrombotic therapy, Cancer, Patient experience, Qualitative research, Thrombosis | Thrombosis research |
| Exploring the professional identity of physicians experienced in older persons’ health care – implications for medical education: A qualitative study. | Moll-Jongerius A et al. | 2025 | Community of practice, Complexity, Medical students, Older persons’ health care, Patient-centeredness, Professional identity formation | BMC medical education |
| Is frailty incremental to the 4C Mortality model for mortality risk prediction in hospitalized older individuals with COVID-19 disease? | Zahra A et al. | 2025 | COVID‐19, Clinical frailty scale, Frailty, Older people, Prognostic research, Vulnerability | Journal of clinical epidemiology |
| Validation of urinary biomarkers for accurate diagnosis of urinary tract infections in older adults across primary care, hospitals and long-term care facilities in the Netherlands and UK (UTI-GOLD): a multicentre observational study protocol. | El Moussaoui N et al. | 2025 | Biomarkers, Infectious Diseases, Urinary tract infections | BMJ open |
| Validation of the acutely presenting older patients tool in a real world setting: results from a large clinical hospital in the Netherlands. | van Groen JC, van Alphen AM, Mooijaart SP, van Noord C, & Ruiter R | 2025 | Emergency department, Frailty, Geriatric assessment, Older patients, Screener | Experimental gerontology |
| Impact of immune-related adverse events on quality of life and physical functioning in older patients with solid tumors treated with immune checkpoint inhibitors. | Özkan A et al. | 2025 | Frailty, Geriatric assessment, Geriatric screening, Immune checkpoint inhibitors, Immune-related adverse events, Physical functioning, Quality of life | European journal of cancer (Oxford, England : 1990) |
| Determining Drug Exposure Based on Medication Dispensing Data: A Validation Study of Vitamin K Antagonist Treatment Episodes Against INR Records. | Kempers EK et al. | 2025 | acenocoumarol, anticoagulants, epidemiologic methods, pharmacoepidemiology, phenprocoumon | Pharmacoepidemiology and drug safety |
| The importance of integrated care. | Haaksma ML, & van den Bos F | 2025 | ageing in place, integrated care, older people, transitions | Age and ageing |
| Rationale and design of ‘discontinuing statins in multimorbid older adults without cardiovascular disease (STREAM)’: study protocol of a randomised non-inferiority clinical trial. | Aebi PS et al. | 2025 | Cardiovascular Disease, GERIATRIC MEDICINE, Lipid disorders, Patients, Primary Health Care, Primary Prevention | BMJ open |
| Quality of vitamin K antagonist treatment during the last year of life. | Visser C et al. | 2025 | HemaSphere | |
| Validation of the acutely presenting older patient screener for short term mortality prediction in older patients hospitalized for COVID-19. | Smits RAL et al. | 2025 | Mortality, Older patients, Screening instrument, Validation | European geriatric medicine |
| The story of pain in people with dementia: a rationale for digital measures. | Patrascu M et al. | 2025 | Challenges, Dementia, Digital phenotyping, Older adults, Pain, Pain assessment, Sensing technology | BMC medicine |
| Trajectories After In-Hospital Delirium: Long-Term Changes in Frailty and Cognition After COVID-19. | Minnema J et al. | 2025 | COVID-19, Delirium, SARS-CoV-2, cognition, frailty, long-term, older adults | Journal of the American Medical Directors Association |
| Considering frailty and meaningful outcomes in geriatric emergency care. | van Oppen JD, Mooijaart S, Nickel CH, & Conroy S | 2025 | Emergency department, Frailty, Health services research, Patient-reported outcome measure, Person-centered care | Internal and emergency medicine |
| Associations between metabolomic scores and clinical outcomes in hospitalized COVID-19 patients. | Venema JA et al. | 2025 | Ageing, COVID-19, Frailty, Metabolomics | GeroScience |
| Music-based therapeutic interventions for people with dementia. | van der Steen JT et al. | 2025 | The Cochrane database of systematic reviews | |
| Temporal Dynamics of Depressive Symptoms, Apathy, Daily Activities, and Cognitive Decline in Older People From the General Population: A Network Analysis. | van der Slot AJC et al. | 2025 | apathy, cognitive impairment, depressive symptoms, network analysis, older people, time series data | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry |
| Older Adults’ Attitudes Toward Deprescribing in 14 Countries. | Vidonscky Lüthold R et al. | 2025 | JAMA network open | |
| A qualitative study regarding older people’s goals of care in relation to frailty status: finding meaning in ‘smaller things’ in life. | van der Klei VMGTH et al. | 2025 | decision-making, older people, patient and public involvement, patient preference, qualitative research, quality of life | Age and ageing |
| The definition of vitality-the perspectives of Dutch older persons. | Jongeneelen ME et al. | 2025 | Ageing, Emic perspective, Healthy ageing, Older people, Succesful ageing, Vitality | BMC public health |
| Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease. | Zahra A et al. | 2025 | COVID‐19, Charlson comorbidity index, Frailty, Nursing home population, Older people, Prognosis research, Vulnerability | BMC geriatrics |
| Discontinuation of anticoagulants and occurrence of bleeding and thromboembolic events in vitamin K antagonist users with a life-limiting disease. | Kempers E et al. | 2025 | Thrombosis and haemostasis | |
| From healthy aging to complex needs in older adults: Onco-geriatric insights from the EuGMS 2024 conference, a report from Young SIOG. | Verri FM, González-Senac NM, Herledan C, van den Bos F, & Neuendorff NR | 2025 | Frailty, Geriatric oncology, Geriatrics, Resilience, Surgical oncology | Journal of geriatric oncology |
| Unplanned Weight Loss and Sarcopenia Across Body Mass Index Categories in Nursing Homes-A Cross-Sectional Study. | Klaassen L, Christoffersen T, Aaslyng MD, & Tetens I | 2025 | community care setting, elderly, muscle loss, nutritional issues, obesity | Nutrients |
| Comparison of diagnostic algorithms used in guidelines on nutritional anaemias in adults. | Roemer MGM et al. | 2025 | PloS one | |
| Adapting a digital monitoring system for self-management to geriatric COPD rehabilitation: A participatory mixed method study. | Debeij SM et al. | 2025 | Pulmonary rehabilitation, agile, blended care, digital health technologies, eHealth, post-acute care, user-centered design | Digital health |
| The influence of the dynamic context of the pandemic on the predictive performance of mortality predictions over time in older patients hospitalised for COVID-19. | van Raaij BFM et al. | 2024 | COVID-19, prediction model, temporal validation | Journal of clinical epidemiology |
| Associations between subclinical thyroid dysfunction and cardiovascular risk factors according to age and sex. | Baretella O et al. | 2024 | Arterial hypertension, Dyslipidemia, LDL-cholesterol, Subclinical hyperthyroidism, Subclinical hypothyroidism, high-sensitivity C-reactive protein | The Journal of clinical endocrinology and metabolism |
| Blood based immune biomarkers associated with clinical frailty scale in older patients with melanoma receiving checkpoint inhibitor immunotherapy. | Tran Van Hoi E et al. | 2024 | Frailty, Immune biomarkers, Immunotherapy by checkpoint inhibition, Melanoma cancer | Immunity & ageing : I & A |
| Activities of persons with dementia at home and after nursing home admission: A survey study. | Groenendaal M, Smaling HJA, Achterberg WP, & Caljouw MAA | 2024 | Activities, Assessment, Dementia, Informal caregivers, Nursing home, Transition | Geriatric nursing (New York, N.Y.) |
| The use of wearable technology in studies in older adults with cancer: a systematic review. | Duin JJ et al. | 2024 | cancer, digital health, geriatric oncology, geriatrics, older adult, oncology, systematic review, wearable electronic devices, wearable technology | The oncologist |
| Which Characteristics are Associated With Going Outside for People Living With Dementia in Nursing Homes? A Cross-Sectional Study. | Velde-van Buuringen MV, Verbeek-Oudijk D, Verbeek H, Achterberg WP, & Caljouw MAA | 2024 | dementia, going outside, nursing homes, quality of life | Journal of applied gerontology : the official journal of the Southern Gerontological Society |
| Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer. | Martens ESL et al. | 2024 | Anticoagulants, Antithrombotic agents, Deprescribing, Flash-mob research, Hemorrhage, Neoplasms, Palliative care, Thrombosis | Thrombosis research |
| Risk assessment and management strategies in older patients with acute pulmonary embolism. | Luijten D et al. | 2024 | Adult, Clinical decision-making, Early discharge, Emergency care, Geriatrics, Outpatient care, Pulmonary embolism, frail older | Journal of thrombosis and haemostasis : JTH |
| Increased 1H-NMR metabolomics-based health score associates with declined cognitive performance and functional independence in older adults at risk of cardiovascular disease. | Zonneveld MH et al. | 2024 | Cognition, Functional independence, Metabolomics | GeroScience |
| Association of Glasgow Prognostic Score with frailty, mortality and adverse health outcomes in older patients with cancer: A prospective cohort study. | van Holstein Y et al. | 2024 | Albumin, C-reactive protein, Functional dependence, Geriatric oncology, Health-related quality of life | Journal of geriatric oncology |
| Use of antithrombotic therapy and the risk of cardiovascular outcomes and bleeding in cancer patients at the end of life: A Danish nationwide cohort study. | Søgaard M et al. | 2024 | Cancer, anticoagulation, deprescribing, palliative care, platelet inhibitor | Journal of thrombosis and haemostasis : JTH |
| Twelve hot questions in the management of hypertension in patients aged 80+ years and their answers with the help of the 2023 European Society of Hypertension Guidelines. | Bahat G et al. | 2024 | Journal of hypertension | |
| DOSAGE study: protocol for a phase III non-inferiority randomised trial investigating dose-reduced chemotherapy for advanced colorectal cancer in older patients. | Baltussen JC et al. | 2024 | CHEMOTHERAPY, GERIATRIC MEDICINE, Gastrointestinal tumours, ONCOLOGY, Quality of Life, Randomized Controlled Trial | BMJ open |
| Allocation and value of curative oncological treatment in frail and fit older patients with esophageal cancer: An observational cohort study. | van der Poort EKJ et al. | 2024 | Esophageal cancer, Frailty, Hospital costs, Patient-relevant outcomes, Value-based health care | Journal of geriatric oncology |
| The association of inflammatory markers with frailty and in-hospital mortality in older COVID-19 patients. | Van Hoi ET et al. | 2024 | Ageing, COVID-19, Frailty, Immunosenescence, Inflammation | Experimental gerontology |
| Person-centred decisions in emergency care for older people living with frailty: principles and practice. | van Oppen JD et al. | 2024 | emergency departments, ethics, frailty, geriatrics | Emergency medicine journal : EMJ |
| The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors. | van Holstein Y et al. | 2024 | Biomarkers, Geriatric assessment, Geriatric oncology, Metabolomics, Mortality | GeroScience |
| Temporal dynamics of depressive symptoms and cognitive decline in the oldest old: dynamic time warp analysis of the Leiden 85-plus study. | van der Slot AJC et al. | 2024 | cognitive impairment, depression, network analysis, older people, oldest old, time series | Age and ageing |
| Effects of the discontinuation of antihypertensive treatment on neuropsychiatric symptoms and quality of life in nursing home residents with dementia (DANTON): a multicentre, open-label, blinded-outcome, randomised controlled trial. | Bogaerts JMK et al. | 2024 | antihypertensive treatment, dementia, deprescribing, hypertension, older people, randomised controlled trial | Age and ageing |
| Differences in characteristics and outcomes of older patients hospitalized for COVID-19 after introduction of vaccination. | Smits RAL et al. | 2024 | COVID-19, Frailty, In-hospital mortality, Older patient, Vaccination | European geriatric medicine |
| Preparing for future pandemics: frailty associates with mortality in hospitalised older people during the entire COVID-19 pandemic, a Dutch multicentre cohort study. | van Raaij BFM et al. | 2024 | COVID-19, Frailty, In-hospital mortality | European geriatric medicine |
| Delirium detection in the emergency department: A diagnostic accuracy meta-analysis of history, physical examination, laboratory tests, and screening instruments. | Carpenter CR et al. | 2024 | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine | |
| Older people’s goals of care in relation to frailty status-the COOP-study. | van der Klei VMGTH et al. | 2024 | decision-making, health outcome prioritisation, older people, patient and public involvement, patient preference | Age and ageing |
| A Systematic Review of Subclinical Hyperthyroidism Guidelines: a Remarkable Range of Recommendations. | Ursem SR et al. | 2024 | European thyroid journal | |
| Geriatric Assessment in CKD Care: An Implementation Study. | Voorend CGN et al. | 2024 | Chronic kidney disease, feasibility studies, geriatric assessment, implementation science, older people, shared decision making | Kidney medicine |
| Patient-reported satisfaction with thyroid hormone replacement therapy for subclinical hypothyroidism in older adults: A pooled analysis of individual participant data from two randomized controlled trials. | Ravensberg J et al. | 2024 | Thyroid : official journal of the American Thyroid Association | |
| The Impact of Delirium on Recovery in Geriatric Rehabilitation After Acute Infection. | Minnema J et al. | 2024 | ADL, COVID-19, Delirium, Geriatric rehabilitation, Older adults, QoL, Recovery | Journal of the American Medical Directors Association |
| Tolerability and effectiveness of palbociclib in older women with metastatic breast cancer. | Baltussen JC et al. | 2024 | Metastatic breast cancer, Older patients, Palbociclib, Real-world data, Tolerability, Toxicity | Breast cancer research and treatment |
| Older patients’ experiences with and attitudes towards an oncogeriatric pathway: A qualitative study. | Uit den Boogaard A et al. | 2024 | Geriatric assessment, Geriatric oncology, Oncogeriatric care pathway, Patient experiences, Qualitative study | Journal of geriatric oncology |
| The impact of the COVID-19 pandemic on Positive Health among older adults in relation to the complexity of health problems. | van der Klei VMGTH et al. | 2024 | COVID-19, community-dwelling, health impact assessment, older adults, self-rated health | Journal of the American Geriatrics Society |
| The Difficulties of Managing Pain in People Living with Frailty: The Potential for Digital Phenotyping. | Collins JT et al. | 2024 | Drugs & aging | |
| Limited incremental predictive value of the frailty index and other vulnerability measures from routine care data for mortality risk prediction in older patients with COVID-19 in primary care. | la Roi-Teeuw HM et al. | 2024 | COVID-19, Frailty, Multiple imputation, Older people, Primary care, Prognosis research, Prognostic factor study, Regression modelling, Vulnerability | BMC primary care |
| Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults | van der Spoel E et al. | 2024 | The Journal of Clinical Endocrinology & Metabolism | |
| Strategies for Identifying Patients for Deprescribing of Blood Pressure Medications in Routine Practice: An Evidence Review. | Sheppard JP, Benetos A, Bogaerts J, Gnjidic D, & McManus RJ | 2024 | Aging, Drug-related side effects and adverse reactions, Frailty, Hypertension, Multi-morbidity, Polypharmacy, Risk prediction | Current hypertension reports |
| External validation of six COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting. | Zahra A et al. | 2024 | COVID-19, COVID-19-Related mortality, External validation, Older population, Prognostic models, clinical prediction models | Journal of clinical epidemiology |
| Diagnostic accuracy of urine biomarkers for urinary tract infection in older women: a case-control study. | Bilsen MP et al. | 2024 | Antimicrobial stewardship, Asymptomatic bacteriuria, Biomarkers, Diagnostic accuracy, Older patients, Urinary tract infection | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases |
| Delirium in older patients with COVID-19: Prevalence, risk factors and clinical outcomes across the first three waves of the pandemic. | Minnema J et al. | 2023 | COVID-19, SARS-CoV-2, delirium, frailty, metabolic encephalopathy, older adults | International journal of geriatric psychiatry |
| Temporal changes in characteristics and external validity of randomized controlled trials in older people from 2012 to 2019. | van Eijk E et al. | 2023 | Geriatric assessments, Older individuals, Randomized controlled trials, Systematic review, Temporal changes | BMC geriatrics |
| Titel | Auteurs | Datum | Trefwoorden | Tijdschrift naam |
Laatste update: 12 mei 2026 op 00:12
